2025-26 Men’s First Round Odds: Spreads, Lines for all 32 Games

Let’s get down to business. Check out the odds for every first-round game in the men’s NCAA Tournament at DraftKings Sportsbook as of March 18. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. THURSDAY, MARCH 19 No. 16 Siena vs. No. 1 Duke Spread: Duke -28.5Moneyline: Duke -20000, Siena +3500O/U: 135.5 No. 16 Howard vs. No. 1 Michigan Spread: Michigan -31.5Moneyline: Michigan -20000, Howard +3500O/U: 151.5 No. 15 Idaho vs. No. 2 Houston Spread: Houston -23.5Moneyline: Houston -8000, Idaho +2200O/U: 138.5 No. 14 Kennesaw State vs. No. 3 Gonzaga Spread: Gonzaga -21.5Moneyline: Gonzaga -4000, Kennesaw State +1600O/U: 154.5 No. 14 North Dakota State vs. No. 3 Michigan State Spread: Michigan State -16.5Moneyline: MSU -1800, ND St. +1000O/U: 143.5 No. 14 Penn vs. No. 3 Illinois Spread: Illinois -24.5Moneyline: Illinois -6500, Penn +2000O/U: 150.5 No. 13 Troy vs. No. 4 Nebraska Spread: Nebraska -13.5Moneyline: Nebraska -1000, Troy +650O/U: 137.5 No. 13 Hawaii vs. No. 4 Arkansas Spread: Arkansas -15.5Moneyline: Arkansas -1450, Hawaii +850O/U: 159.5 No. 12 High Point vs. No. 5 Wisconsin Spread: Wisconsin -10.5Moneyline: Wisconsin -500, High Point +380O/U: 163.5 No. 12 McNeese vs. No. 5 Vanderbilt Spread: Vanderbilt -11.5Moneyline: Vanderbilt -700, McNeese +500O/U: 150.5 No. 11 South Florida vs. No. 6 Louisville Spread: Louisville -4.5Moneyline: Louisville -205, South Florida +170O/U: 164.5 No. 11 VCU vs. No. 6 UNC Spread: UNC -2.5Moneyline: UNC -155, VCU +130O/U: 152.5 No. 11 Texas vs. No. 6 BYU Spread: BYU -1.5Moneyline: BYU -148, Texas +124O/U: 159.5 No. 10 Texas A&M vs. No. 7 Saint Mary’s Spread: Saint Mary’s -3.5Moneyline: Saint Mary’s -162, Texas A&M +136O/U: 146.5 No. 9 TCU vs. No. 8 Ohio State Spread: Ohio State -2.5Moneyline: Ohio State -142, TCU +120O/U: 146.5 No. 9 Saint Louis vs. No. 8 Georgia Spread: Georgia -1.5Moneyline: Georgia -148, Saint Louis +124O/U: 169.5 FRIDAY, MARCH 20 No. 16 LIU vs. No. 1 Arizona Spread: Arizona -30.5Moneyline: Arizona -100000, LIU +5000O/U: 150.5 No. 15 Tennessee State vs. No. 2 Iowa State Spread: ISU -24.5Moneyline: ISU -8000, Tennessee State +2200O/U: 149.5 No. 15 Queens U vs. No. 2 Purdue Spread: Purdue -25.5Moneyline: Purdue -8000, Queens U +2200O/U: 163.5 No. 15 Furman vs. No. 2 UConn Spread: UConn -20.5Moneyline: UConn -4500, Furman +1700O/U: 136.5 No. 14 Wright State vs. No. 3 Virginia Spread: Virginia -18.5Moneyline: Virginia -2800, Wright State +1300O/U: 145.5 No. 13 Hofstra vs. No. 4 Alabama Spread: Alabama -11.5Moneyline: Alabama -800, Hofstra +550O/U: 159.5 No. 13 Cal Baptist vs. No. 4 Kansas Spread: Kansas -14.5Moneyline: Kansas -1200, Cal Baptist +750O/U: 138.5 No. 12 Akron vs. No. 5 Texas Tech Spread: Texas Tech -7.5Moneyline: Texas Tech -340, Akron +270O/U: 156.5 No. 12 Northern Iowa vs. No. 5 St. John’s Spread: St. John’s -9.5Moneyline: St. John’s -535, UNI +400O/U: 131.5 No. 10 Missouri vs. No. 7 Miami FL Spread: Miami -1.5Moneyline: Miami -130, Missouri +110O/U: 147.5 No. 10 Santa Clara vs. No. 7 Kentucky Spread: Kentucky -3.5Moneyline: Kentucky -162, Santa Clara +136O/U: 160.5 No. 10 UCF vs. No. 7 UCLA Spread: UCLA -5.5Moneyline: UCLA -250, UCF +205O/U: 152.5 No. 9 Utah State vs. No. 8 Villanova Spread: Utah State -1.5Moneyline: Utah State -125, Villanova +105O/U: 146.5 No. 9 Iowa vs. No. 8 Clemson Spread: Iowa -2.5Moneyline: Iowa -135, Clemson +114O/U: 128.5